Expression and Significance of CD133+ Cells in Peripheral Blood in Patients with Acute Cerebral Infarction

Hong Xiao¹, Qin Yang¹, Ming Cheng^2*

¹Department of Neurosurgery, The First People's Hospital of Liangjiang New Area, Chongqing 401121, Chongqing, China - ²Department of Ophthalmology, Chongqing Youyoubaobei Women’and Children's Hospital, Chongqing 401122, Chongqing, China

Objective: The goals of this article are to study the expression of peripheral venous blood positive (CD133+) cells in acute cerebral infarction, to explore the correlation between expression and clinical information in patients with cerebral infarction and to evaluate the value in predicting high-risk factors for stroke.

Method: This study employs experimental comparison, using flow cytometry to determine the infarction group of patients with acute cerebral infarction within the onset of 30 cases. Inpatients with cerebrovascular risk factors but no cerebral infarction were selected as the control group. The neurological deficit score (NIHSS) and the volume of the infarct lesion in the infarct group were recorded.

Results: The percentage of peripheral blood cells in the infarct group was lower than that of the control group; the difference was statistically significant (P<0.05). The percentage of CD133+ cells in the peripheral blood of patients with different infarct lesion volumes in the infarct group was significantly lower than that of the control group. Moreover, the percentage of peripheral CD133+ blood cells in the large lesion group was lower than that of the middle lesion group, and the percentage of peripheral blood CD133+ cells in the medium lesion group was lower than that of the small lesion group—all with statistical significance (P<0.05). The baseline number of peripheral blood EPCc in the cerebral infarction group was significantly lower than that of the control group (t=-6.046, P<0.01).

Conclusion: Corresponding conclusions are drawn through data comparison. After the experiments, the CD133+ cell levels in the peripheral blood of patients in the acute phase of cerebral ischemia was significantly reduced, and the peripheral blood CD133+ cell levels in patients with acute cerebral infarction is related to the degree of neurological deficit and the volume of the infarct focus. CD133+ levels have the value of predicting degrees of neurological damage in ischemic stroke.