EFFECT OF PARECOXIB SODIUM ON SURVIVAL RATE OF REPLANTATION OF AMPUTATED FINGERS AND PATIENTS’ ANALGESIA

Zhanqiao Ma^#, Qian Zhang^#, Heng Liu^*

Department of Anesthesiology, Cangzhou Hospital of Integrated TCM-WM•Hebei, Cangzhou, 061001, Hebei, China 

Objective: To investigate the effect of parecoxib sodium on the survival rate of replantation of amputated fingers and the patients’ analgesia. 

Methods: One hundred patients who had completely amputated finger and underwent the replantation of amputated fingers in the Department of Anesthesia of Hebei Cangzhou Hospital of Integrated TCM-WM (February 2019 - January 2020) were selected as the research objects, and they were randomly divided into treatment group (50 cases) and control group (50 cases). All the patients received the axillary brachial plexus block. The patients in the treatment group were given 40 mg of parecoxib sodium when entering the operating room, at the end of surgery and at 24 hours after surgery, while the control group received the equivalent amount of 0.9% normal saline. 

Results: Compared with the control group, the treatment group achieved remarkably lower pain scores at 6 hours after surgery (T1), 24 hours after surgery (T2) and 48 hours after surgery (T3; P<0.001). Compared with the control group, the replanted capillary refilling time in the treatment group was much lower (P<0.05). The survival rates of replantation of amputated fingers in the treatment group and control group were 100% (50 cases) and 90.0% (45 cases), respectively, and the rate in the treatment group was remarkably higher compared with the control group (P<0.05). 

Conclusion: Parecoxib sodium improves the surgery condition of the patients undergoing replantation of amputated fingers, relieves their postoperative pain and is beneficial to enhance the survival rate of replantation of amputated fingers, so it should be promoted in practice.