CORRELATION BETWEEN SERUM URIC ACID LEVEL AND BLOOD PRESSURE, BLOOD LIPID, BLOOD GLUCOSE AND CRP IN PATIENTS WITH ACUTE CEREBRAL INFARCTION

Dayan He, Yuhong Yang^*

Department of Neurology, The First People's Hospital of Chuzhou City, Chuzhou 239000, Anhui Province, China

Objective: This study aimed to analyze the correlation between serum uric acid (SUA) level and blood pressure, blood lipids, blood glucose, and C-reactive protein (CRP) in patients with acute cerebral infarction. 

Methods: We selected 113 patients with cerebral infarction admitted to the Department of Neurology of our hospital from December 2017 to December 2020 as the observation group, while 65 healthy people who came to our hospital for a normal physical examination in the same time frame were selected as the control group. SUA, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and systolic blood pressure (SBP) were detected by automatic biochemical analyzer. Changes in SBP, DBP, FBG, and CRP were analyzed using Pearson's correlation. 

Results: The levels of TC, TG, LDL-C, SBP, DBP, FBG, SUA, and CRP in the observation group were significantly higher than those in the control group, while the observation group's HDL-C level was significantly lower than that in the control group (P<0.05). The SUA level in members of the moderate and severe groups was significantly higher than that of the mild group (P<0.05); moreover, the value for the severe group was significantly higher than that of the moderate group (P<0.05). The levels of TC, TG, LDL-C, SBP, DBP, FBG, and CRP in hyperuricemia patients were significantly higher than those in the control group, while the former's HDL-C levels were significantly lower than those in the non-hyperuricemia patients (P<0.05). Pearson correlation analysis showed that SUA was positively correlated with TC, TG, LDL-C, SBP, DBP, FBG, and CRP levels but negatively correlated with HDL-C (P<0.05). 

Conclusion: An increase in SUA level is closely related to the incidence of acute cerebral infarction. Moreover, the level is related to the severity of cerebral infarction, blood pressure, blood lipids, blood glucose, and CRP levels. Thus, controlling these risk factors for cardiovascular and cerebrovascular diseases is vital for the clinical treatment of cerebral infarction.