CLINICAL VALUE OF SERUM ST2, PCIII AND SVCAM-1 IN DIAGNOSING THE SEVERITY OF ELDERLY HYPERTENSION COMPLICATED WITH LEFT MYOCARDIAL HYPERTROPHY

Chongzhe Yang^{1, #}, Weichi Jiang^{2, #}, Jie Li1, Zhenlei Ren¹, Zhiyong Deng¹, Yun Zhou¹, Yuqin Wang¹, Feng Liu^{1, *}

¹Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China - ²Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China

Introduction: To analyze the clinical value of serum soluble ST2 (sST2), type III procollagen (PCIII) and serum soluble vascular adhesion factor sVCAM-1 (sVCAM-1) in the diagnosis of elderly hypertension complicated with left myocardial hypertrophy.

Materials and methods: A total of 120 elderly patients with hypertension were selected for the study, and the patients were divided into two groups according to whether they had left myocardial hypertrophy or not. There were 80 cases in the hypertension group and 40 cases in the hypertension and left myocardial hypertrophy group, and 40 cases of healthy subjects in our hospital during the same period were selected as the control group. Fasting venous blood was collected from all subjects, and the expression levels of ST2, PCⅢ and sVCAM-1 were analyzed for the clinical value of diagnosing hypertension complicated with left myocardial hypertrophy.

Results: Serum sST2, PCⅢ, sVCAM-1 in the control and the hypertension group were significantly lower than those in the hypertension and myocardial hypertrophy group. Furthermore, in the correlation row results, high systolic blood pressure and serum sST2 levels were directly correlated with the development of left ventricular hypertrophy, and serum sST2 levels were more strongly correlated than systolic blood pressure. Positive correlation between serum levels of sST2, PCIII and sVCAM-1 and left ventricular mass index (LVMI) in patients with hypertension combined with myocardial hypertrophy (P<0.05).

Conclusion: Serum sST2, PCⅢ and sVCAM-1 have clinical value in diagnosing the severity of hypertension in patients with left myocardial hypertrophy. sST2 is a related factor of left ventricular hypertrophy.