Clinical application of Tanreqing injection combined with nutritional support in patients with acute exacerbation of chronic obstructive pulmonary disease

Lingying Song¹, Chibing An², Qian Liu², Yong Chen¹, Xiaowei Qian^1*

¹Department of critical care, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science And Technology, Hubei Province,China-437100 - ²Department of Emergency, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science And Technology, Hubei Province, China-437100

Introduction: The purpose of this study was to investigate the clinical application value of Tanreqing injection combined with nutritional support (enteral nutrition emulsion TPF-T) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients.

Materials and method: A total of 126 AECOPD patients admitted to our hospital from January 2017 to February 2021 were randomly divided into study group (n=63) and control group (n=63) according to a random number table. Tanreqing injection was used in control group. In the study group, nutritional support (enteral nutrition emulsion TPF-T) was added on the basis of the control group. Nutrition indexes serum Hb (Hb) , total lymphocyte count (TLC) ,pre-albumin (PA), albumin (ALB), serum TF (TF) ; serum immunoglobulins IgA, IgG and IgM and serum inflammatory markers CRP, IL-1β, COX-2 and PGE2 levels were compared.

Results: After treatment, the levels of serum Hb, TLC, PA, ALB and TF in study group were significantly higher than those in control group (all p< 0.001); serum immunoglobulin indexes IgA, IgG and IgM in study group were higher than those in control group (p = 0.003, 0.008 and 0.025, respectively);levels of serum inflammatory markers CRP, IL-1β, COX-2, and PGE2 in the study group were lower than those in control group (p<0.001, p=0.001, p=0.032 and p=0.014, respectively).

Conclusion: Tanreqing injection combined with nutritional support (enteral nutrition emulsion TPF-T) can improve nutrition and immune indexes and reduce the level of inflammation in AECOPD patients, so it has certain clinical application value.