CLINICAL APPLICATION OF CONTINUOUS RENAL REPLACEMENT THERAPY IN PATIENTS WITH ACUTE RENAL INJURY CAUSED BY SEPTIC SHOCK

Zhangjian Xu^#, Yi Zhang^#, Peiqing Li, Fuhui Duan, Chunyan Li, Jing Yu^* 

Department of Nephrology, Baoshan People's Hospital, Baoshan, PR China

Objective: To explore the clinical application of continuous renal replacement therapy (CRRT) in patients with acute renal injury caused by septic shock. 

Methods: 103 patients with acute renal injury caused by septic shock treated in our hospital from August 2019 to September 2020 were selected as research subjects for this experiment and divided into experimental (52 cases) and control (51 cases) groups according to treatment method. The control group was treated using intermittent hemodialysis (IHD), while the experimental group was treated with CRTT; all patients were given anti-infection, anti-shock and blood volume expansion treatment. For both groups of patients, we compared general data, analyzed blood creatinine, urea nitrogen, procalcitonin, and C-reactive protein levels before and after treatment, evaluated postoperative related indices, compared total bilirubin levels before and after treatment, and analyzed survival rates. 

Results: serum creatinine, urea nitrogen, procalcitonin and C-reactive protein levels were significantly lower in the experimental group than in the control group (P<0.05); organ support time, urine volume recovery time, ICU hospitalization time and total hospitalization time were significantly reduced for the experimental group in comparison with the control group (P<0.05); and bilirubin levels were also significantly lower in the experimental group than in the control group (P<0.05). Furthermore, survival rates were 69.23% for the experimental group (36 cases surviving) and 31.37% for the control group (16 cases surviving); the survival rate for patients in the experimental group was significantly higher than for the control group, and the difference was statistically significant (χ²= 14.762, P<0.001). 

Conclusion: CRRT can effectively regulate levels of serum creatinine, urea nitrogen, procalcitonin and C-reactive protein, reduce total bilirubin, improve postoperative survival rates and shorten hospital stays for patients with acute renal injury caused by septic shock.