APPLICATION OF CHARACTERISTIC ERAS IN THE PERIOPERATIVE PERIOD OF LAPAROSCOPIC COLORECTAL CANCER AND ITS EFFECT ON THE INTESTINAL MUCOSAL BARRIER

Xiao Cheng^*, Cao Bo, Li Meiling, Li Zhi

The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China

Introduction: To investigate the application effect of characteristic Enhanced Recovery after Surgery (ERAS) in the perioperative period of laparoscopic colorectal cancer. 

Materials and methods: A total of 40 colorectal cancer patients admitted to the Anorectal Disease Hospital of Guizhou University of Traditional Chinese Medicine from July 2019 to July 2020 were randomly selected and equally divided into treatment group (characteristic ERAS protocol) and control group (traditional regimen). For comparison between the two groups, clinical efficacy, intestinal barrier function (peripheral blood diamine oxidase, bacterial endotoxin, D-lactate level), postoperative VAS pain score, Hamilton anxiety score, KPS score, hospitalization cycle and safety indicators were observed.

Results: The clinical efficacy, peripheral blood diamine oxidase, bacterial endotoxin, D-lactate level, anxiety score and KPS score of the treatment group were significantly outperformed to the control group, and the above difference was statistically significant (P<0.05).

Conclusion: Through the clinical research plan and the analysis of relevant data before and after treatment, it is concluded that patients with colorectal cancer generally have preoperative anxiety and depression, low quality of life, and characteristic ERAS can significantly improve the anxiety and depression state of the patients. This study obviously improves the quality of life of patients and has the prevention and treatment effect of intestinal barrier function after colorectal cancer, which is feasible and effective in laparoscopic colorectal cancer perioperative period.