Ping He, Jingjing Hu*


Department of Ultrasound, tShanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China


Introduction: To explore the clinical value of three-dimensional ultrasound technology in predicting fetal malformations in embryo transfer.

Materials and methods: 203 pregnant women between 15-38 weeks of gestation undergo routine ultrasound screening in the obstetric center. All pregnant women undergo two-dimensional ultrasound examination first, and then apply three-dimensional ultrasound technology to dynamically observe the fetus. The analysis of the effects of the two ultrasound diagno3D methods at different gestational weeks The detection rate and accuracy of fetal malformation diagnosis, as well as the sensitivity, specificity and positive predictive value of different inspection methods in the detection of malformed fetuses.

Results: 203 pregnant women gave birth to 256 fetuses, and 245 fetuses were successfully evaluated by ultrasound screening. A total 64 fetal malformations were detected. Among them, 60 were found by three-dimensional ultrasound, and 28 were found by two-dimensional ultrasound technology. Three-dimensional ultrasound technology in diagnosing fetal malformations is about 93.6%, which is significantly higher than 43.8% of pure two-dimensional ultrasound, p<0.05. Three-dimensional ultrasound technology has high sensitivity and specificity in detecting skeletal malformations in fetuses. The total accuracy of three-dimensional ultrasound technology in detecting neurological malformations is 93.8%. Compared with two-dimensional ultrasound, its sensitivity, specificity, and positive and negative predictive values are 75%, 98.1%, 90.1%, and 94.0%, respectively, which is obvious Higher than three-dimensional ultrasound. 

Conclusion: Ultrasound is the preferred imaging method for prenatal diagnosis of fetal malformations. Three-dimensional ultrasoundcan effectively improve the diagno3D accuracy and reduce the missed diagnosis rate. At the same time, three-dimensional ultrasound technology has high clinical application value in diagnosing fetal congenital heart disease during pregnancy. 


Embryo transfer, fetal malformation, three-dimensional ultrasound technology, clinical application.