EFFECT OF SINGLE-HOLE THORACOSCOPIC SEGMENTAL PNEUMONECTOMY ON PERIOPERATIVE IMMUNE FUNCTION IN PATIENTS WITH LUNG CANCER

Lin Zhang, Jianglong Wang, Bing Zhu^*

Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Objective: The aim of this study was to evaluate the effectiveness of single-hole thoracoscopic segmental pneumonectomy and its effect on perioperative immune function in patients with lung cancer. 

Methods: The study group included 66 patients with non-small cell lung cancer (NSCLC) treated in our hospital between August 2020 and August 2021. According to the operative technique used on the patient, they were assigned to either the single-hole group or the three-hole group, with 33 patients in each group. Single-hole thoracoscopic segmental resection was performed for the single hole group and three-hole thoracoscopic segmental resection was performed for the three-hole group. The general data of the two groups were compared. Blood levels of D3⁺, CD4⁺, and CD8⁺ cells, and the CD4⁺/CD8⁺ ratio were reported before and after operation, the operation-related indexes of the two groups were evaluated, and the postoperative clinical efficacy of the treatment and quality-of-life scores were compared between the groups. 

Results: The levels of CD3⁺, CD4⁺, and CD8⁺ cells, and the CD4⁺/CD8⁺ ratio in the single-port group were significantly higher than those in the three-port group (P<0.05); the operative time of single hole group was significantly longer than that of three hole group, and the catheterisation time and duration of hospitalisation were significantly shorter than those of three hole group (P<0.05). The total efficacy rate of 75.76% (25/33) in the single hole group was significantly higher than 45.45% (15/33) in the three hole group (P<0.05). The physiological function, physical pain, social function, and emotional function of the single hole group were significantly higher in the single-port group than the three hole group (P<0.05). 

Conclusion: Single hole thoracoscopic segmental pneumonectomy can effectively shorten the hospital stay, reduce the impact on patients’ immune function, improve the success rate of the procedure, and improve the quality of life of patients after operation.