EFFECT OF DOXOFYLLINE COMBINED WITH TIOTROPIUM BROMIDE ON THE EFFICACY AND AIRWAY REMODELING STATUS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Yufei Lian^{1, #}, Yue Zhang^{1, #}, Yunjia Feng¹, Xuejia Qiu¹, Shuhui Gao², Li Yan^{2, *}

¹Department of Pharmacy, Hebei Provincial People's Hospital, Shijiazhuang, Hebei050051, China - ²Department of Respiratory Medicine, Hebei Provincial People's Hospital, Shijiazhuang, Hebei050051, China 

Objective: To investigate the effect of doxofylline combined with tiotropium bromide on the efficacy and airway remodeling status of chronic obstructive pulmonary disease. 

Methods: Two hundred and fourteen patients with chronic obstructive pulmonary disease admitted to our hospital from April 2018 to April 2021 were selected. The random number table method was used to divide the cases into control and observation groups, 107 cases each. The control group was treated with doxofylline and the observation group was treated with doxofylline combined with tiotropium bromide. Inflammatory factors, lung function, and airway remodeling indexes were measured before and after treatment to compare the symptom scores and clinical efficacy of the two groups.

Results: After treatment in both groups, hypersensitive C-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-17 (IL-17), interleukin-18 (IL-18), peak airway pressure (PIP), matrix metalloproteinase-9 (MMP-9), transforming growth factor-β (TGF-β), airway wall area (AWA), airway wall area as a percentage of total airway area (WA%), airway wall thickness to airway outer diameter ratio (T/D), basic fibroblast growth factor (BFGF), vascular endothelial growth factor (VEGF), chronic obstructive pulmonary disease symptom assessment (CAT), St George's Respiratory Questionnaire score ( SGRQ), and dyspnea score (MRC) decreased compared to the pre-treatment period (p<0.05). FEV1, FVC, FEV1/FVC and PEF increased in both groups after treatment compared to pre-treatment (p<0.05). The hs- CRP, TNF-α, IL-8, IL-10, IL-17, IL-18, PIP, MMP-9, TGF-β, AWA, WA%, T/D, BFGF, VEGF, CAT score, SGRQ score, and MRC score were lower in the observation group than those in the control group after treatment (p<0.05). FEV1, FVC, FEV1/FVC, and PEF were higher in the observation group compared with the control group after treatment (P<0.05). The total effective rate of the observation group was higher than that of the control group (P<0.05). 

Conclusion: Doxofylline combined with tiotropium bromide is effective in the treatment of chronic obstructive pulmonary disease and can improve the state of airway remodeling.