DIAGNOSTIC VALUE OF QUANTITATIVE ULTRASONOGRAPHIC ANALYSIS IN PATIENTS WITH ENDOMETRIAL CANCER AND ITS CORRELATION WITH MICROVASCULAR DENSITY

Chunmei Jiao^1#, Dan Han^2#, Ligong Lu³, Jie Tan^4* 

¹Department of gynaecology and obstetrics, Civil Aviation General Hospital, Beijing 100000, China - ²Department of ultrasound, Ezhou Central Hospital, Ezhou, Hubei 436000, China - ³Departmnet of interventional radiology, Zhuhai hospital affiliated with Jinan University (Zhuhai People's Hospital), Zhuhai, Guangdong, 519000, China - ⁴Department of ultrasound imaging, Wuhan Hankou Hospital, Wuhan, Hubei 430012, China.

Objective: To investigate the diagnostic value of quantitative ultra-sonographic analysis in patients with endometrial cancer and its correlation with microvascular density. 

Methods: 60 patients with endometrial cancer who attended our hospital from January 2019 to June 2020 were selected as the observation group, and 60 patients with benign uterine lesions were allocated to the control group during the same period. Ultrasonography was performed to collect the onset time (AT), peak time (TP), peak intensity (Peak), area under the curve (AUC), mean transit time (MTT), and local blood volume (RBF), as well as to calculate ΤAT, ΤTP, ΤPeak, ΤAUC, ΤMTT, and ΤRBF. The differences between the two groups were analyzed. 

Results: Compared with the control group, the observation group had a shorter Peak (34.83±19.05 vs. 43.28±12.48, P=0.010), reduced RBF (32.84±10.93 vs. 53.74±12.62, P=0.000), reduced ΤAT (-2.73±0.90 vs. 1.88± 0.43, P= 0.000), decreased ΤTP (-4.88±1.84 vs. -2.25±1.72, P=0.000), increased ΤPeak (0. 72±0. 32 vs. -4. 38±2. 47, P=0.000), increased ΤPeak (0. 72±0. 32 vs. 38±2. 47, P=0. 000), decreased ΔMTT (3.33±0.93 vs. 10.72±2.85, P= 0.000), and increased ΔRBF (1. 92±0. 54 vs. -5. 24±1. 88, P= 0. 000). Pearson’s linear correlation analysis showed that microvessel density in endometrial cancer tissues was negatively correlated with Peak, RBF, ΤAT, ΤTP, and ΤMTT, and positively correlated with ΤPeak and ΤRBF (P<0.05). 

Conclusion: Quantitative ultra-sonographic analysis has a diagnostic value for the diagnosis of endometrial cancer and is associated with microvascular density.