CURRENT STATUS OF OCCURRENCE, RELATED RISK FACTORS AND NURSING INTERVENTIONS OF PICC-ASSOCIATED VENOUS THROMBOSIS IN PATIENTS WITH LUNG CANCER CHEMOTHERAPY

Cheng Min^{1, 2, 3, 4}, Ding Lili^{1, 2, 3, 4, *}, Wang Yanli^{1, 2, 3, 4}, Li Huaying^{1, 2, 3, 4}, Lin Xiuqin^{1, 2, 3, 4} 

¹Shanxi Bethune Hospital, Taiyuan, 030032, China - ²Shanxi Academy of Medical Sciences, Taiyuan, 030032, China - ³Tongji Shanxi Hospital, Taiyuan, 030032, China - ⁴Third Hospital of Shanxi Medical University, Taiyuan, 030032, China

Objective: To analyze the occurrence status of PICC-associated venous thrombosis, related risk factors and nursing interventions in the patients with lung cancer chemotherapy. 

Methods: 250 patients with lung cancer chemotherapy admitted to the Chest Oncology Department, Shanxi Bethune Hospital from January 2018 to June 2021 were included with their retrospective data in this study. According to the occurrence of the PICC-associated venous thrombosis, the patients were divided into PICC-associated venous thrombosis group (n=26) and PICC-unassociated venous thrombosis group (n=224). The related risk factors occurring in the two groups were analyzed by multivariate Logistic regression analysis. 

Results: In the 250 patients with lung cancer chemotherapy, 26 cases occurred with the PICC-associated venous thrombosis with the incidence rate 10.40% (26/250). The Karnofsky (KPS) ≤50, the TNM Ⅲ~Ⅳ, the pathological classification of adenocarcinoma, the proportion of 2/3 patients on the superior vena cava at the position of the catheter tip, and the serum level of D dimer (D-D) of the PICC-associated venous thrombosis group is higher than that of the PICC-unassociated venous thrombosis group. The multivariate Logistic analysis showed that the TNM Ⅲ~Ⅳ, the pathological classification of adenocarcinoma, the proportion of 2/3 patients on the superior vena cava at the position of the catheter tip, and the plasma D-D levels are the related factors (OR=2.273, 1.881, 3.529, 2.212, P<0.05) to the PICC-associated venous thrombosis in patients with lung cancer chemotherapy. 

Conclusion: The incidence of PICC-associated venous thrombosis in patients with lung cancer chemotherapy is high and closely related to the TNM Ⅲ~Ⅳ, the pathological classification of adenocarcinoma, the proportion of 2/3 patients on the superior vena cava at the position of the catheter tip, and the plasma D-D levels are the related factors. Thus, targeted nursing interventions can be given clinically according to the above indicators to reduce the occurrence risks.