CORRELATION BETWEEN THE EXPRESSION OF SERUM MIR-2861 AND MIR-34A AND THE PROGNOSIS OF CVVH IN PATIENTS WITH ACUTE RENAL FAILURE

Jihong Liu, Lixia Zhang, Huidan Guo, Xiaoli Gong^* 

Department of Nephrology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province, China

Objective: This study’s aim is to observe the correlation between the expression of serum microRNA-2861 (miR-2861) and miR-34a, and the prognosis of continuous veno-venous hemofiltration (CVVH) in patients with acute renal failure (ARF). 

Methods: As prospective research subjects, 112 ARF patients were selected who had been admitted to the hospital from January 2018 to January 2020. Baseline data of the patients were recorded; the serum levels of miR-2861 and miR-34a were detected; CVVH was performed; and the prognosis of the patients was evaluated. Next, the relationship between the expression of serum miR-2861 and miR-34a; the prognosis of CVVH; and the predictive value of the expression of serum miR-2861 and miR-34a for the prognosis of CVVH, were analysed.

Results: Among 112 ARF patients, 25.00% had poor prognosis; after preliminary comparison via logistic regression analysis of the baseline data between the group with poor prognosis group and the group with good prognosis, the results showed that a high score of acute physiology and chronic health (APACHE Ⅱ); up-regulation of serum creatinine; blood urea nitrogen; white blood cell count; and miR-34a relative expression, were risk factors for poor prognosis in ARF patients (OR > 1, p < 0.05). Furthermore, the results showed that low 24-hour urine volume and low relative expression of miR-2861 were protective factors for poor prognosis in ARF patients (OR < 1, p < 0.05). The receiver operating curve (ROC) was drawn, and indicated that the area under the curve (AUC) of the relative expression of serum miR-2861 and miR-34a for single and combined prediction of prognosis in ARF patients were all > 0.70, which had certain predictive value; the AUC for the joint prediction was the largest. 

Conclusion: ARF patients have a high risk of poor prognosis, which is closely related to APACHE Ⅱ score, renal function index, white blood cell count, and relative expression of miR-2861 and miR-34a; in addition, miR-2861 and miR-34a can be used to predict poor prognosis for ARF patients.