URIC ACID AND MORTALITY RELATIONSHIP IN COVID-19

Deniz Çekiç^{1, *}, Selçuk Yaylacı¹, Kubilay İşsever², Ahmed Cihad Genç³, Didar Şenocak⁴, Ahmed Bilal Genç¹, Sümeyye Çekiç¹, İlhan Yıldırım⁵, Hamad Dheir⁶, Ceyhun Varım¹, Oğuz Karabay⁷, Ali Tamer¹

¹İnternal Medicine/ Faculty of Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey - ²İnternal Medicine, Toyota State Hospital, Sakarya, Turkey - ³İnternal Medicine, Hendek State Hospital, Sakarya, Turkey - ⁴İnternal Medicine, Haydarpaşa Numuna Trainig and Research Hospital, İstanbul, Turkey - ⁵İnternal Medicine, Görele State Hospital, Giresun, Turkey - ⁶Neprology Department/ Faculty of Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey - ⁷İnfectious Disease/ Faculty of Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey

Aim: The present study aims to investigate and compare the uric acid of the recovered/deceased and ICU/ward COVID-19 patients.

Method: The study was conducted with 397 patients with COVID-19 diagnosis. Information about 157 deceased and 240 recovered COVID-19 patients was analyzed retrospectively. Relationship between serum uric acid, Na, K, urea, and creatinine was investigated between patients in the mortal/non-mortal and ICU/ward group.

Result: Of the total 397 patients in the study, 158 (39,8%) were female and 239 (60,2%) were male. Statistically significant difference in mortality was found between males and females in order (107-239, 44.8%/50-158,31, 7%; p=0.009). Total mean age (std deviation), was 63.77±16,1, the mean age in the deceased group was 71,41±11, 39, and it was 58.78±16,8 in the survived group and that is statistically significant too (p=0.001). The mean values of Uric acid with order survivor and deceased group ((4,867±1,81 (n=222)-7, 086±3,24(n=148), P=0,000). Mean age in ICU group 69.53±12,52, in the ward group 56.24±17,1 and this age differentiation between two groups is statistically significant (p=0,001), There is a statistically significant difference in ICU care or ward was found between males and females in order (107-239, 44.8%/50-158,31,7%; p=0.009). The mean values of Uric acid with order ICU care and ward group ((6,52 ±3,1(n=217) -4,66±1,46 (n=153), P=0,000)). Serum K+ (Potassium) (4,164±0,5 (n=239)) - 4,357±0,7 (n=157), P=0,002)) levels are higher in deceased groups. The cutoff value of uric acid, which may pose a risk of mortality, was found to be 5,15 mg/dl. And the cutoff value of creatinine, which may pose a risk of mortality, was found to be 0,9 mg/dl.

Conclusion: The cutoff value of uric acid, which may pose a risk of mortality, was found to be 5,15 mg/dl and the cutoff value of creatinine, which may pose a risk of mortality, was found to be 0,9 mg/dl. Advanced age, uric acid, creatinine, and potassium increase were found to be associated with mortality.