THE IMPORTANCE OF ADIPONECTIN GENE POLYMORPHISMS IN THE STABILIZATION OF ATHEROSCLEROTIC PLAQUES

Ozlem Secen¹, Arzu Senol^{2, *}

¹Department of Cardiology, Elazig Fethi Sekin City Hospital, Elaziğ, Turkey - ²Department of Clinical Microbiology and Infectious Disease, Elazig Fethi Skin City Hospital, Elaziğ, Turkey

Objective: Some studies have indicated that adiponectin gene polymorphisms are related to coronary artery disease, and they play a role in the stabilization of atherosclerotic plaques. In this study, we aimed to investigate adiponectin gene polymorphisms in the stabilization of atherosclerotic plaques in patients with coronary artery disease (CAD).

Methods: One hundred patients who had a myocardial infarction with ST-elevation (Group1) , 100 patients who had a coronary artery bypass graft operation (Group2) , and as the control group , 100 patients (68 males, 32 females, mean age: 54.8 ± 8.4 years) who had coronary angiography due to suspected CAD and appeared to have normal coronary arteries (Group3) were included in the study. Adiponectin gene polymorphisms (rs 1501299; +276 G >T, rs2241766; +45 T >G) of the participants were determined using real-time polymerase chain reaction method.

Results: The number of mutant GG base pairs of adiponectin at rs2241766 were smaller in Group 2 when compared to Group 1 and Group 3, and the difference was statistically significant (p=0.0001). Although the G allele frequencies of adiponectin at rs2241766 were similar in Groups 1 and 3 (p>0.05), the G allele frequencies in Group 2 were smaller when compared to Groups 1 and 3, and the difference was statistically significant (p=0.0001). 

Conclusion: We suppose that adiponectin gene polymorphisms can be interpreted as a risk factor.