Study on the expression of LncRNA H19/HOTAIR in patients with PTC and its relationship with tumor proliferation and invasion

Zhengwen Du, Yajie Wang, Ju Wang, Jing Zhou, Chuanming Tong, Yuan Zhang^*

Department of General Surgery, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, China

Objective: To investigate the expression of long-stranded non-coding (Lnc) RNA H19/HOTAIR in patients with papillary thyroid carcinoma (PTC) and the relationship with tumor proliferation and invasion. 

Methods: A total of 70 patients with PTC admitted to our hospital from January 2019 to June 2020 were included in the study, and the clinicopathological characteristics data were analyzed, and the expression levels of LncRNA H19/HOTAIR in cancer tissue, para-cancer tissue and normal thyroid tissue were detected by real-time quantitative PCR to evaluate the correlation between LncRNA H19/HOTAIR expression and clinicopathological characteristics. 

Results: Lnc RNA H19/HOTAIR levels in thyroid cancer tissues were significantly higher than those in both para-cancer and normal tissues (P<0.05); the differences in Lnc RNA H19/HOTAIR levels between para-cancer and normal tissues were not statistically significant (P>0.05); the results of univariate analysis showed that LncRNA H19 and LncRNA HOTAIR expression were both associated with the maximum tumor diameter, TNM stage and lymph node metastasis of patients (P<0.05). 

Conclusion: Both LncRNA H19/HOTAIR were highly expressed in patients with PTC, and both expressions were also associated with tumor proliferation and invasion.