PREDICTIVE VALUE OF NEUTROPHIL TO LYMPHOCYTE RATIO FOR HOSPITAL MORTALITY RISK IN PATIENTS WITH ACUTE CORONARY SYNDROME

Yuqin Zhou^1,*, Chaojun Yang^2,*, Wanyin Cai² 

¹Department of Cardiology, Wuxi Clinical College of Anhui Medical University, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, 214044, China - ²Department of Cardiology, the First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China, Hubei Province, China

Objective: To investigate the value of neutrophils to lymphocyte ratio (NLR) in predicting the risk of hospitalization death in patients with acute coronary syndrome (ACS). 

Methods: A total of 308 patients with ACS admitted to the first college of clinical medical sciences of China Three Gorges University and 904th Hospital of Joint Logistic Support Force of PLA from January 2016 to December 2020 were enrolled. The results of blood examination were collected and NLR was calculated. The receiver operating characteristic (ROC) curve was used to evaluate the value of NLR in predicting the hospitalization death, and multivariate logistic regression model was used to analyze the risk factors of hospitalization death. 

Results: ACS patients with NLR>6.39 had a higher mortality during hospitalization than those with NLR≤6.39 (P<0.05). ROC curve showed that when the cut-off value of NLR was 6.39, the sensitivity and specificity of predicting hospitalization death were 90.5% and 52.4% respectively. Multivariate logistic regression analysis showed that NLR was a predictor of hospitalization death in patients with ACS (OR=9.85, 95%CI: 1.46~21.26, P=0.02). 

Conclusions: NLR may be a valuable biomarker as a predictor of mortality risk during hospitalization in patients with ACS.