Observational study on the cerebral protection of rats in cardiopulmonary bypass by Danhong injection

Fan Ouyang¹, Yufang Du^2,#, Qifei Li^3,*

¹Department of Operating Room, Wuhan No.1 Hospital, Wuhan, Hubei, 430000, PR China - ²Department of Operating room, West China Hospital, Sichuan University, Chengdu, Sichuan, 61004, PR China - 3Department of Anesthesiology, The First People's Hospital of Jingzhou (The First Affiliated Hospital of Yangtze University), Jingzhou, Hubei, 434020, China 

Cerebral protection in cardiopulmonary bypass (CPB) is a hot and difficult issue of great concern in clinical work. The mechanism of brain injury in CPB is very complex, and reducing postoperative neurological injury has become a current research hotspot in the field of cardiac surgery. Danhong injection is a Chinese herbal injection extracted from the active ingredients of Salvia miltiorrhiza and Safflower, which can antioxidant response and reduce inflammatory response, and it is widely used in cardiac and cerebral insufficiency of blood supply, but there are few reports on its use for cerebral protection during cardiopulmonary bypass in cardiac surgery, and its mechanism is yet to be clarified. In this study, we established a cardiopulmonary bypass model in rats and selected Danhong injection for intervention to observe the effect of Danhong injection on cerebral injury after cardiopulmonary bypass in rats. The results showed that the brain edema was significantly reduced after pretreatment with Danhong injection, which had a protective effect on cerebral injury in cardiopulmonary bypass, and its effect might be through upregulating the expression of DCX and CB to reduce brain edema.