EXPRESSION OF TIPE2 IN COLON CANCER AND ITS CORRELATION WITH CLINICOPATHOLOGICAL FEATURES AND PROGNOSIS

Jinpin Chen¹, Bo Liu², Jing Hu^{1, *}

¹Fuxing Hospital Affiliated to Capital Medical University GI Medicine, Beijing 100038, China - ²The fifth medical center of PLA General Hospital, Beijing 100039, China

Objective: To investigate the expression of tumor necrosis factor α induced protein 8-like factor 2 (TIPE2) in colon cancer and its correlation with clinicopathological features and prognosis.

Methods: The cancer tissues and paracancerous tissues of 56 cases of colon cancer patients treated in our hospital from January 2018 to March 2019 will be included in this study. Immunohistochemical method was used to detect the positive expression of TIPE2 in colon cancer and its paracancerous tissues, and the correlation between its expression level and clinicopathological features and prognosis of colon cancer patients was analyzed in depth. 

Results: The positive expression rate of TIPE2 in colon cancer tissues was 73.21% (41/56), and that in paracancerous tissues was 16.07% (9/56). The difference of positive expression rate between the two groups was statistically significant (P<0.05). TIPE2 expression level was associated with lymph node metastasis and Dukes stage of colon cancer (P<0.05), but not with age, gender and differentiation degree (P>0.05). The 5-year survival rate of patients with positive TIPE2 expression was 63.41 months, and that of patients with negative TIPE2 expression was 80.00 months. There was no statistically significant difference in the 5-year survival rate between the two groups (P>0.05). Lymph node metastasis and Dukes stage were independent risk factors for prognosis of colon cancer patients.

Conclusion: The expression level of TIPE2 in colon cancer tissues was increased, and its expression level was correlated with the clinicopathological features of colon cancer patients.