EXPRESSION OF PHLDA2 IN COLON CANCER AND ITS CORRELATION WITH CLINICOPATHOLOGICAL FEATURES AND PROGNOSIS

Fuxing Liu¹, Xiuming Li^{2, *} 

¹Department of Pathology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China - ²Department of Ultrasound, Taizhou People' s Hospital, Taizhou 225300, Jiangsu Province, China

Objective: To investigate the expression of the platelet leukocyte C kinase substrate homologous domain protein family 2 (phlda2) in colon cancer and its correlation with clinicopathological features and prognoses. 

Methods: 103 patients with colon cancer who were treated in our hospital in January of 2014 were selected, and their colon cancer tissues were collected. Also, 30 cases of colon cancer adjacent tissues preserved in the pathology department of our hospital at the same time were collected. The expression level of phlda2 in colon cancer tissues and adjacent tissues was detected by immunohistochemistry, and the correlations between the expression level, clinicopathological characteristics, and prognoses were analyzed. 

Results: The high expression rate of phlda2 was 68.93% (71/103) in colon cancer tissues and 23.33% (7/30) in paracancerous tissues. There was a significant difference between the two groups (P<0.05). The expression of phlda2 was correlated with lymph node metastasis and TNM stage (P<0.05) but not with age, gender, tumor grade, or distant metastasis (P>0.05). The median survival time of patients with high expression of phlda2 was 12 months, and the median survival time of patients with low expression of phlda2 was 26 months. There was a significant difference between the two groups regarding median survival time (P<0.05). Univariate and multivariate analysis showed that lymph node metastasis, TNM stage, and expression of phlda2 were independent risk factors for the prognoses of patients with colon cancer. 

Conclusion: The expression level of phlda2 in colon cancer tissue is significantly increased, and its expression level is related to lymph node metastasis, TNM stage, and prognosis. The phlda2 expression level can participate in the occurrence and development of colon cancer, and it is expected to become an important index by which to evaluate the prognoses of patients with colon cancer.