EXPRESSION AND CORRELATION OF SERUM HMGB1, NE, AND IL-1Β IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Rui Wu, Sifang Feng, Hongli Quan, Yun Zhang, Rong Fu, Hong Li*

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi 'an Jiaotong University, xi 'an 710061, Shaanxi Province, China

Objective: To analyze the expression level of serum high mobility group protein 1 (HMGB1), neutrophil elastase (NE), interleukin-1 β (IL-1β) in patients with chronic obstructive pulmonary disease (COPD) and its correlation with pulmonary function.

Methods: We selected 118 COPD patients who were admitted to the respiratory department of our hospital from April 2018 to November 2019 as the study objects. According to the severity of the disease, they were divided into an acute exacerbation group (58 cases) and a stable group (60 cases). In addition, 40 healthy people who had a physical examination in our hospital at the same time were selected as the normal control group. The expression levels of HMGB1, NE, and IL-1β in serum from all the subjects were detected by ELISA and a pulmonary function instrument. The ratio of forced expiratory volume to forced vital capacity (FEV1/FVC) and FEV1% PRED in the first second was measured. Pearson analysis was used for correlation analysis. 

Results: The serum levels of HMGB1, NE, and IL-1β in the acute exacerbation group and the stable group were significantly higher than those in the normal control group (P<0.05). The serum levels of HMGB1, NE, and IL-1β in the acute exacerbation group were significantly higher than those in the stable group (P<0.05). FEV1% PRED and FEV1/FVC in the acute exacerbation group and the stable group were significantly lower than those in the normal control group (P<0.05). FEV1% PRED and FEV1/FVC in the acute exacerbation group were significantly lower than those in the stable group (P<0.05). Serum HMGB1, NE, and IL-1β were negatively correlated with pulmonary function indexes in patients with acute exacerbation, and, in the stable stage, serum HMGB1 was positively correlated with NE and IL-1β, and NE was positively correlated with IL-1β (P<0.05).

Conclusion: The expression levels of HMGB1, NE, and IL-1β in the serum of COPD patients were significantly increased and were negatively correlated with FEV1/FVC and FEV1% PRED. The three indexes can reflect the severity of COPD patients to a certain extent, which is worthy of clinical application.