EXPRESSION AND CLINICAL DIAGNOSTIC VALUE OF SERUM SUPAR, NF-ΚB AND AQP1/5 IN PATIENTS WITH SEVERE PNEUMONIA

Wendan Wang^{1, *}, Qiong Wu², Yufeng Zeng³ 

¹Department of Internal Medicine, The Hospital of Zhejiang University, Hangzhou 310000, Zhejiang Province, China - ²Department of Pediatrics, Zhoushan Women and Children's Hospital, Zhoushan 316000, Zhejiang Province, China - ³Department of Respiratory Medicine, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou 325000, Zhejiang Province, China

Objective: To investigate the expression and clinical diagnostic value of serum soluble urokinase-type plasminogen activator receptor (suPAR), nuclear factor kappa B (NF-κB) and aquaporin 1/5 (AQP1/5) in patients with severe pneumonia. 

Methods: A total of 51 cases of severe pneumonia and 51 cases of common pneumonia, treated in our hospital from July 2018 to May 2020, were randomly selected. A total of 51 healthy subjects who simultaneously underwent a physical examination at our hospital were selected as the control group. The clinical data, serum suPAR, NF-κB and AQP1/5 levels were compared among the three groups. Pearson’s correlation test was used to analyze the relationship between the serum suPAR, NF-κB, AQP1/5 levels and the intensity of severe pneumonia. Logistic regression analysis was used to examine the risk factors of severe pneumonia. A receiver operating characteristic (ROC) curve was established to analyze the clinical diagnostic value of the serum suPAR, NF-κB and AQP1/5 levels in severe pneumonia. 

Results: In comparison with the control group, the levels of white blood cells (WBC) and neutrophil (Neu) in the severe pneumonia and common pneumonia groups were significantly increased (P < 0.05). In comparison with the common pneumonia group, the pneumonia severity index (PSI) score of the severe pneumonia group was significantly higher (P<0.05). In comparison with the control group, the serum levels of the suPAR, NF-κB and AQP1/5 in the common pneumonia group were significantly increased (P < 0.05), and in comparison with the common pneumonia group, the serum levels of the suPAR, NF-κB and AQP1/5 in the severe pneumonia group were significantly increased (P<0.05). Pearson’s correlation test showed that the serum suPAR, NF-κB and AQP1/5 levels were positively correlated with the PSI score (P<0.05). An ROC curve was established. The results showed that the area under the curve of the serum suPAR, NF-κB and AQP1/5 were 0.780, 0.791, 0.775 and 0.946, respectively. The area under the curve of the combined detection was significantly higher than that of the single detection, and the specificity and sensitivity of the combined detection were significantly higher than that of the single detection. Logistic regression analysis showed that the suPAR, NF-κB and AQP1/5 were independent risk factors for the development of severe pneumonia. 

Conclusion: The levels of serum suPAR, NF-κB and AQP1/5 in patients with severe pneumonia were significantly higher than those in patients with severe pneumonia. The levels of these indicators were of great significance for the diagnosis of severe pneumonia, and they were independent risk factors of the disease.