CORRELATION BETWEEN SERUM SDC4 AND SEVERITY OF IDIOPATHIC INTERSTITIAL PNEUMONIA

Yanqin He^#, Linfeng Shi^#, Chunyan Li, Yanling Kuang, Meiyan He^*

Department of Respiratory Medicine, Xishuangbanna Dai Autonomous Prefecture People's Hospital, Xishuangbanna 666100, China

Methods: From September 2018 to August 2019, 56 patients with IIP who were diagnosed and treated in our hospital for the first time were selected for the IIP group, 56 patients with nonspecific interstitial pneumonia were selected for the NSIP group, and 56 healthy people were selected for the normal control group. The levels of SDC4 in serum were measured by ELISA; FVC, FEV1, TLC, DLCO, and PaO2 were detected by a lung function instrument; HRCT scores were evaluated by the Muller method. The changes in serum SDC4 level, pulmonary function, and HRCT score were observed, and the correlation between serum SDC4 and HRCT score was analyzed. 

Results: Compared with the normal control group, neutrophils and leukocytes in the NSIP group and the IIP group were significantly increased (P<0.05), and lymphocytes were significantly decreased (P<0.05). Neutrophils and leukocytes in the IIP group were significantly higher than those in the NSIP group (P<0.05), and lymphocytes were significantly lower than those in the NSIP group (P<0.05). SDC4 levels in the NSIP and IIP groups were higher than those in the normal control group. SDC4 levels in the IIP group were significantly higher than those in the NSIP group (P<0.05). The levels of FEV1 in the IIP and NSIP groups were significantly higher than in the normal control group (P<0.05), and the levels of FVC, TLC, DLCO, and PaO2 in the IIP group were significantly higher than in the NSIP group (P<0.05). The levels of FVC, TLC, DLCO, and PaO2 in the IIP group were significantly higher than in the NSIP group (P<0.05). In the NSIP group, SDC4 levels were significantly decreased (P<0.05); serum SDC4 levels were significantly positively correlated with FEV1 (P<0.05) and negatively correlated with FVC, TLC, DLCO, and PaO2 (P<0.05); serum SDC4 was positively correlated with HRCT score in the IIP and NSIP groups (P<0.05). 

Conclusion: Serum SDC4 is closely related to the severity of IIP. Regular monitoring of SDC4 water serum concentration can determine the severity of lung interstitial damage.