CORRELATION BETWEEN SERUM PAF, G-CSF, AND SE-SLT LEVELS AND SEVERITY OF ACUTE PANCREATITIS

Dingchuan Chen^{1, #}, Sheng Ye^{1, #}, Jiasi Wang², Hengbing He^{3, *}

¹Department of Clinical Laboratory, The GEM Flower Hospital of Sichuan, Chengdu 610213, PR China - ²Department of Clinical Laboratory, Central Hospital of Dazhou, Dazhou 635000, PR China - ³Department of Clinical Laboratory, People's Hospital of Linshui, Guang’an 638500, PR China

Objective: To analyze the correlation between the changes of serum platelet activating factor (PAF), granulocyte colony stimulating factor (G-CSF), and soluble E-selectin (SE-SLT) in patients with acute pancreatitis (AP). 

Methods: Seventy-two cases of AP patients in our hospital from August 2019 to July 2020 were selected and divided into a mild acute pancreatitis group (MAP group) with 36 cases and a severe acute pancreatitis group (SAP group) with 36 cases; 72 healthy people were selected as the normal control group. The Ranson score, CTSI, Balthazar CT grade, and levels of serum PAF, G-CSF, and SE-SLT were compared and analyzed between the MAP group and the SAP group, as well as the control group. Spearman correlation was also used to analyze the correlation between serum PAF, G-CSF, SE-SLT, and severity of disease. 

Results: Compared with the normal control group, the levels of PAF, G-CSF, and SE-SLT in the MAP group and the SAP group were significantly higher (P<0.05), and the levels of PAF, G-CSF, and SE-SLT in the SAP group were significantly higher than those in the MAP group (P<0.05). The levels of serum PAF, G-CSF, and SE-SLT in the SAP group were significantly higher than those in non-death group (P<0.05). Compared with the normal control group, the Ranson score and cts of the MAP group and the SAP group were significantly increased (P<0.05), and the SAP group was significantly higher than the MAP group, and the difference was statistically significant (P<0.05); the serum PAF, G-CSF, and SE-SLT in the MAP group and the SAP group were significantly positively correlated with Ranson score and CTSI (P<0.05).

Conclusion: The serum levels of PAF, G-CSF, and SE-SLT are higher in patients with acute pancreatitis, and they are related to the severity of the disease and the prognosis. It is of great importance to evaluate the severity of acute pancreatitis and use that information as a guide to clinical diagnosis, treatment, and prognosis.