CORRELATION BETWEEN SERUM FIBULIN-3 LEVEL AND LIPIDS, LVPWT, IVST, BAPWV IN ELDERLY PATIENTS WITH HYPERTENSION

Jiaoxia Yang, Jun Xie, Fengmin Gao, Ling Liu, Xiaolei Qin, Xiaoyu Qiu, Jifang Guo^*

Hongqi Hospital Affiliated with Mudanjiang Medical University, Mudanjiang, PR China

Objective: To analyze the correlation between serum fibulin-3 level and blood lipids, brachial-ankle pulse wave velocity (baPWV), left ventricular posterior wall thickness (LVPWT), and interventricular septal thickness (IVST).

Methods: From June 2017 to April 2019, 45 elderly patients with hypertension who were admitted to the Department of Cardiology of our hospital were selected as the observation group, and another 45 healthy people were selected as the control group. We compared the correlation between serum fibulin-3 level and blood lipids (TC, FFA, TG, HDL-C, LDL-C), brachial-ankle pulse wave velocity (baPWV), left ventricular posterior wall thickness (LVPWT), and interventricular septal thickness (IVST).

Results: The level of fibulin-3 in the observation group was significantly lower than that in the control group (P<0.01); the level of HDL-C in the observation group was significantly lower than that in the control group (P<0.01); the level of LVPWT and IVST in the observation group was significantly higher than that in the control group (P<0.01); the level of baPWV in the observation group was significantly lower than that in the control group (P<0.01); fibulin-3 and HDL-C were positively correlated with TC, TG and LDL-C. Fibulin-3 was negatively correlated with LVPWT and IVST, and positively correlated with baPWV (P<0.05).

Conclusion: The level of fibulin-3 in the elderly patients with hypertension was lower than that in the healthy control group, which was closely related to LVPWT, IVST, and baPWV, and therefore it can be used as an important index to prevent and judge the disease.