CORRELATION BETWEEN SCD146 AND NT-PROBNP AND WATER LOAD IN HEMODIALYSIS PATIENTS WITH END-STAGE RENAL DISEASE AND ITS DIAGNOSTIC VALUE

Chunqiu Liu, Lijuan Hao, Jianya Gao, Xianhong He, Qingyun Mou, Jun Wang^*

Three Gorges Hospital Affiliated to Chongqing University, Chongqing, PR China

Objective: To analyze the relationship between soluble CD146 (sCD146), N-terminal pro-brain natriuretic peptide (NT-proBNP), and water load in hemodialysis patients with end-stage renal disease (ESRD).

Methods: From June 2018 to October 2019, 50 ESRD patients were selected for hemodialysis in the blood purification center of our hospital. The MEXF value of excess water in the body was calculated. The patients were divided into 32 cases of abnormal water load and 18 cases of normal water load. The general data of the patients were collected. The resistance and reactance values were determined by whole-body measurement. The ECV, ICV, TBW, and MEXF were calculated. A Pearson analysis of the levels and main factors of sCD146 and NT-proBNP ROC curve was used to analyze the clinical value of sCD146 and NT-proBNP in diagnosing excessive water load.

Results: The ECV of the group with abnormal water load before dialysis was significantly higher than that of the group with normal water load (P<0.05). The resistance of the group with abnormal water load after dialysis was significantly lower than that of the group with normal water load, and the MEXF was significantly higher than that of the group with normal water load (P<0.05). Before dialysis, the level of sCD146 was negatively correlated with age and positively correlated with MEXF (P<0.05), and the level of NT-proBNP was positively correlated with the MEXF and ECV/TBW ratio (P<0.05). The level of sCD146 in the group with abnormal water load before and after dialysis was significantly higher than that in the group with normal water load (P<0.05). The level of NT-proBNP water in the 2 groups after dialysis was significantly lower than that before dialysis, and that in the group with normal water load was significantly lower than that in the group with abnormal water load (P<0.05). The area under the curve of sCD146 and NT-proBNP was 0.724 and 0.723, respectively. The 2 indexes had the same value in diagnosing water overload, but NT-proBNP had better specificity.

Conclusion: sCD146 and NT-proBNP were positively correlated with water overload in ESRD hemodialysis patients, and both can be used as biomarkers for the diagnosis of water overload.