CHANGES AND SIGNIFICANCE OF CIC, CRP, IMMUNOGLOBULIN AND COMPLEMENT IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Hanwei Wang¹, Xiaoyue Wang¹, Chenxi Li¹, Zhixiang Gao^{2, *} 

¹Department of Rheumatology and Immunology, the Third People's Hospital of Bengbu City, Bengbu 233000, Anhui Province, China - ²Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Objective: To explore the changes and significance of CIC, CRP, immunoglobulin and complement in patients with systemic lupus erythematosus. 

Methods: Forty-two patients with systemic lupus erythematosus who were treated in our hospital from June 2018 to April 2020 were randomly selected as the study group. Forty-two healthy subjects who had had physical examinations in our hospital at the same time were selected as the control group. The age, gender, blood pressure and other basic clinical data of the two groups were compared. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum CIC level of the study group and the control group, and the changes of serum CRP, immunoglobulin, and complement content in the two groups were measured by scattering rate method. Pearson correlation test was used to analyze the correlation among CIC, CRP, immunoglobulin and complement levels in patients with systemic lupus erythematosus. 

Results: There was no significant difference in age, gender, BMI, blood pressure and heart rate between the two groups (P>0.05). Compared with the control group, the levels of serum CIC, CRP, IgA, IgM and IgG in the study group were significantly increased, while the levels of complement C3 and complement C4 were significantly decreased (P<0.01). Pearson correlation analysis showed that the CIC level was positively correlated with CRP, IgA, IgM and IgG, and negatively correlated with complement C3 and C4 (P<0.05). The sensitivity and specificity of complement C3 and C4 were 71.34, 90.32, 65.01 and 83.77 respectively, and the area under the curve was 0.831 and 0.745 respectively, which were significantly higher than those of CIC, CRP, IgA, IgM and IgG. Complement C3 and C4 have higher value in the diagnosis of systemic lupus erythematosus. 

Conclusion: CIC, CRP, immunoglobulin and complement levels in patients with systemic lupus erythematosus were significantly abnormal, and the above indicators can be used as important indicators to judge the development of systemic lupus erythematosus.