THE VALUE OF TUMOUR MARKER EXPRESSION IN THE PATHOLOGICAL DIAGNOSIS AND PROGNOSIS EVALUATION OF GASTRIC CANCER

Jianing Ding¹, Yifeng Zang², Yinlu Ding^{2, *}

¹Medicine, Queen Mary School, Medical College of Nanchang University, Nanchang 330031, PR China - ²Department of Gastrointestinal Surgery, the Second Hospital of Shandong University, Jinan 250033, PR China

Objective: To explore the value of tumour marker expression in the pathological diagnosis and prognosis evaluation of gastric cancer.

Methods: 60 subjects were selected as group A by our hospital; 60 subjects were selected as group B by our hospital; 60 subjects were selected as group C by our hospital. The study period was from June 2016 to March 2018. In the early morning, fasting blood samples were taken to observe the expression level and concentration of tumour markers for gastrointestinal cancer antigen (CA242), serum carcinoembryonic antigen (CEA), gastric cancer and ovarian cancer antigen (CA724), the expression level of tumour markers for all stages of cancer in group C, and data on the effects of prognosis evaluations were gathered.

Results: The expression levels of tumour markers in group B and group C were higher than those in group A, which was statistically significant (P<0.05); for serum concentration, the concentrations of group C were higher than those in groups A and B, which was statistically significant (P<0.05) With the staging of tumours, the expression level of tumour markers in group C showed an upward trend. Among patients with relapse, the positive cases of tumour markers were higher than the negative ones, which was statistically significant (P<0.05).

Conclusion: For gastric cancer patients, early diagnosis and treatment can effectively promote the recovery of patients and the detection of tumour markers can effectively improve diagnostic accuracy for gastric cancer and provide high diagnostic value for follow-up treatment and rehabilitation.