Chunyan Wang1, He Wang1, Haibin Wu2, Ronggang Li2, Yilin Zeng1, Deming Song1, *


1Heart Diagnosis And Treatment Center, Shanghai Public Health Clinical Center, Shanghai, PR China - 2Department of Neurosurgery, Shanghai Public Health Clinical Center, Shanghai, PR China


Objective: The aim of this study was to investigate the clinical effect of dexmedetomidine on myocardial function in cardiopulmonary bypass (CPB) valve replacement.

Methods: From November 2018 to May 2019, 80 patients undergoing CPB valve replacement in our hospital were randomly divided into a control group and an observation group, with 40 patients in each group. The control group was given normal saline and the observation group was given dexmedetomidine. The indexes of myocardial injury, haemodynamics, and improvement of cardiac function were compared between the two groups. 

Results: CK-MB, cTnI, and H-FABP levels in the observation group were lower than those in the control group at different time periods following operation (P<0.05). The haemodynamic stability of the observation group was significantly better than that of the control group (P<0.05). The improvement of the overall cardiac function in the observation group was better than that of the control group. 

Conclusion: The application of dexmedetomidine in CPB heart valve replacement can reduce myocardial injury after CPB, promote the improvement of cardiac function, and has little effect on haemodynamics.


Cardiac valve replacement, cardiopulmonary bypass, dexmedetomidine, myocardial function.