RISK FACTORS OF BLOOD-BRAIN BARRIER INJURY IN PATIENTS WITH ACUTE ISCHEMIC STROKE AND ITS RELATIONSHIP WITH PROGNOSIS OF ENDOVASCULAR THERAPY

Jiajia Zhang, Hang Zhou, Chensong Deng, Wenju Gu^*

Department of Neurology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi City, Hubei Province, 435000, PR China

Introduction: To investigate the risk factors of blood-brain barrier injury in patients with acute ischemic stroke (AIS) and its relationship with the prognosis of endovascular therapy. 

Materials and methods: 223 patients with AIS undergoing endovascular therapy in our hospital from January 2019 to January 2022 for AIS were included retrospectively. All patients were grouped according to blood-brain barrier injury and divided into injury group (135 cases) and non-injury group (88 cases). The clinical features and prognostic indicators of two groups were compared. Logistic regression model was used to evaluate the independent risk factors of blood-brain barrier injury, and the relationship between blood-brain barrier injury and prognosis of endovascular therapy was further analyzed.

Results: The proportion of diabetes history, random blood glucose level, baseline National Institutes of Health Stroke Scale (NIHSS) score, proportions of cardiogenic embolism, internal carotid artery occlusion, middle cerebral artery occlusion and 90-day mortality in the injury group were significantly higher than those in the non-injury group (P<0.05). The proportion of 90-day mRS≤1 in the injury group was significantly lower than that in the non-injury group (P<0.05). Multivariate analysis of logistic regression model showed that cardiogenic embolism, high baseline NIHSS score, internal carotid artery occlusion and middle cerebral artery occlusion were independent risk factors for blood-brain barrier injury (P<0.05). Multivariate analysis of logistic regression model showed that blood-brain barrier injury was an independent risk factor for poor prognosis in patients with AIS after endovascular therapy (P<0.05). 

Conclusion: The incidence of blood-brain barrier injury in patients with AIS is closely related to the presence of car-diogenic embolism, baseline NIHSS score, internal carotid artery occlusion and middle cerebral artery occlusion. The presence of blood-brain barrier injury often indicates a higher risk of poor prognosis.