EFFECT OF EARLY IMMUNE ENTERAL NUTRITION SUPPORT ON NUTRITIONAL STATUS AND LYMPHOCYTES IN PATIENTS WITH SEVERE CEREBROVASCULAR DISEASE

Changxiu Li¹, Wei Chen², Xun Li³, Yanyan Yu², Zhixia Jiang^{4, *}

¹School of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, PR China - ²Department of Cerebrovascular Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, PR China - ³Department of Clinical Nutrition, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, PR China - ⁴Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, PR China

Objective: To determine the effect of early immune enteral nutrition support on nutritional status and lymphocytes in patients with severe cerebrovascular disease.

Methods: A total of 80 patients with severe cerebrovascular disease were enrolled in our hospital from January 2019 to January 2020. The subjects were divided into an experimental group (n=40) and a control group (n=40) according to the difference in nutritional support. The control group received general nutrition support, while the experimental group received early immune enteral nutrition support. The nutritional status and lymphocyte status of the two groups were compared.

Results: Upon comparing the PA, ALB and TF indexes of two groups of patients, the results showed that there was no significant difference in the treatment data between the two groups before treatment (P>0.05). After treatment, the PA, ALB and TF index data of the two groups were compared (P<0.05). Upon comparing the two groups of patients with CD3, CD4⁺, CD8⁺ and CD4⁺/CD8⁺, the results indicated no significant difference in all data between the two groups before treatment (P>0.05). After treatment, index results from the two groups were compared (P<0.05). The GCS and APACHE II scores of the two groups were compared, with the results showing that P>0.05 before treatment. After treatment, the experimental group was significantly better (P<0.05) than the control group. The results indicated that there was no significant difference in the IL-2 and IL-4 data between the two groups before treatment (P>0.05), while the results of the two groups after treatment were also compared (P<0.05).

Conclusion: Early immune enteral nutrition support has a significant impact on patients with severe cerebrovascular disease. Notably, it can effectively improve PA, ALB, TF and T lymphocyte subsets as well as GCS scores. Simultaneously, it can reduce the APACHE II score of patients while also improving their nutritional status and immune function, which makes this treatment worthy of effective promotion and use.