CORRELATION BETWEEN COAGULATION FUNCTION AND INFLAMMATORY CYTOKINE LEVELS IN PATIENTS WITH ICU SEPSIS

Yakun Zhan¹, Bei Zou², Yan Luo^{3, *} 

¹Department of Emergency and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China - ²Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, China - ³Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China

This paper investigates the relationship between plasma prothrombin time (PT), activated partial thrombin time (APTT) and procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) in patients with ICU sepsis. Correlation, provide a reference for clinical treatment of ICU sepsis patients. The prognosis of coagulation function and inflammatory cytokine levels were compared, and the relationship between coagulation function and inflammatory cytokines was analyzed. Compared with non-septic patients, PT, APTT, CRP, PCT, and WBC were significantly increased in patients with sepsis (P<0.001). Compared with survival group, death group PT, APTT, CRP PCT and WBC indicators were significantly increased (P<0.001); sepsis serum PT, APTT, PCT were positively correlated with CRP and WBC. The WBC, CRP and PCT indicators can be combined in the pre-diagnosis of patients with sepsis. The dynamic monitoring of coagulation function can predict the severity of the patient's condition, which is of great significance for clinical rational treatment and prognosis evaluation.