CORRELATION ANALYSIS OF SERUM PAI-1, UPA, MCP-1 AND BLOOD LIPID LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Maomao Xu^*, Hong Yu, Jie Zhao, Yu Zhang, Xiaoxiao Wang

Department of Gynecology and Obstetrics, Huaibei Hospital of Traditional Chinese Medicine, Huaibei 235000, Anhui Province, China

Objective: To analyse changes in plasminogen activator inhibitor-1 (PAI-1), urokinasetype plasminogen activator (uPA) and monocyte chemoattractant protein-1 (MCP-1) and correlation with blood lipids (TG, TC, HDL-C, LDL-C) levels in the serum of patients with polycystic ovary syndrome (PCOS).

Methods: A total of 43 PCOS patients who visited our hospital from April 2018 to March 2019 were selected. The PCOS group was divided according to BMI into an obese group (BMI≥25kg/m²) and non-obese group (BMI<25kg/m²). There were 21 cases in the obese group and 22 cases in the non-obese group. In addition, 22 patients in the outpatient clinic of our hospital with male fertility problems or fallopian tube concerns were selected as the normal control group. Concentration changes in PAI-1, uPA, MCP-1, TG and TC, A, HDL-C, LDL-C, ApoA, ApoB, Lp(a) were measured using enzyme-linked immunosorbent assay (ELISA). The chemiluminescence method was used to detect changes in PRL, LH, FSH, E2 and T levels.

Results: The serum PAI-1 and MCP-1 of the PCOS group were significantly higher (p<0.05) than those of the control group. No significant differences (p>0.05) were found in levels of serum uPA, LDL-C, HDL-C, TG and TC between the PCOS group and the control group. Levels of PAI-1 and MCP-1 in the obese PCOS group were significantly higher (p<0.05) than those in the non-obese PCOS group, while the difference in serum uPA levels was not statistically significant (p>0.05). Compared with the control group, the levels of PAI-1 and MCP-1 in the obese PCOS group and the non-obese PCOS group were significantly higher (p<0.05); no significant differences (p>0.05) were found in in serum uPA levels. PAI-1 levels in PCOS patients were positively correlated (p<0.05) with TC and LDL-C, and negatively correlated (p<0.05) with HDL-C and TG. There was no significant correlation between uPA level and TC, TG, LDL-C, HDL-C (p>0.05). MCP-1 level was not significantly correlated (p>0.05) with TC, LDL-C, HDL-C, but positively correlated (p<0.05) with TG.

Conclusion: Serum PAI-1, uPA, and MCP-1 have an important influence on the blood lipid levels of PCOS patients, and the combined detection is beneficial to assess the condition and prognosis of PCOS.