Shang-Zhi Han1, Xin Lv1, Xi-Bo Chen1, Ying-Ying Xu1, Feng Huo1, *, Zi-Jing Yu2, *


1Department of Stomatology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China - 2Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China


Objective: Concentrated growth factor (CGF) which is a new regeneration platelet aggregate containing various growth factors is used widely in bone regeneration and dermatic and soft tissue repair. Although an increasing number of papers related to CGF are published, currently, no macroscopic overviews of CGF based on bibliometric analysis have been carried out. The purpose of the study was to analyze the hotspots and research trends focusing on CGF.

Methods: Publications on CGF from 2007 to 2021 in the Web of Science database were retrieved. Relevant citations data were analyzed and visualized by bibliometrix R-based software and VOSviewer software.

Results: A total of 118 publications from 75 journals with average 16.03 citations were retrieved and the number of publications and citations increased over time. China was the most productive region accounting for 47.5% of papers published, while the United States ranked first regarding the total citations and average citations per paper. The special journal J Craniofac Surg published the most publications (4.2%). Rodella LF had the highest number of publications and published one of top10 most cited articles. The keywords analysis revealed that “regeneration”, “proliferation”, “differentiation”, “osteogenesis”, “tissue engineering” may be the latest, promising research hotspots in this field. Most of the top10 cited CGF studies were concentered in prosthodontics and craniofacial restoration. 

Conclusion: Our study for the first time presents several important insights into the bibliometric features and research trends of CGF research. The research frontiers were the mechanism and effect of CGF in oral prosthodontics and craniofacial restoration.


Bibliometric analysis, concentrated growth factor, research trends, citation.