Xuli Wang1, Guangchun Xu1, Qi Wang2, Yanrong Wang3, *


1Department of Hematology, Tianjin 4th Central Hospital, Tianjin, PR China - 2Department of Hemodialysis Room, Tianjin 4th Central Hospital, Tianjin, PR China - 3Department of Gastroenterology, Tianjin 4th Central Hospital, Tianjin, PR China


Chronic diarrhoea is a common clinical symptom in the digestive system that usually manifests as abdominal discomfort and increased stool. Microscopic colitis is a group of clinicopathological syndromes characterised by chronic watery diarrhoea, normal colonic mucosa under colonoscopy, and special changes under colonoscopy. The incidence of microscopic colitis is increasing yearly. Colonoscopy of patients with microscopic colitis is generally normal or close to normal, and chronic diarrhoea is similar to microscopic colitis in clinical symptoms, so microscope colitis is easily misdiagnosed as chronic diarrhoea, and the misdiagnosis rate is as high as 80%. However, approaches to treating the two diseases differ, so the differential diagnosis of the two diseases has important clinical significance. This paper primarily investigates the prevalence of microscopic colitis among patients with negative colonoscopy, analyses whether chronic diarrhoea and microscopic colitis are related to gender, and finally attempts to determine the number of patients with microscopic colitis. In the following experiment, 1500 patients with chronic diarrhoea who arrived at our hospital for examination were used as the experimental group, and the endoscopic results of 1230 healthy people were used as the control group; the ratio of gender in the experimental group with negative colonoscopy was also analysed. A microscopic colitis examination was performed on patients with chronic diarrhoea who were colonoscopy-negative, and the ratio of patients with microscopic colitis and colitis-negative patients with chronic diarrhoea were analysed, and the following results were obtained: among 1500 patients with chronic diarrhoea, 55% had organic disease, and among these 55% patients, 33% showed microscopic colitis. The proportion of women suffering from microscopic colitis was the same as that of male patients. The prognosis of microscopic colitis is positive and it may be considered a benign disease.


Chronic diarrhoea, colonoscopy of patients, microscopic colitis, organic lesions.