Bo Yu, Shi Tan*
Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China
Objective: To investigate the clinical effect of ultrasound-guided and intracavitary AIH in a randomized controlled trial of ovulatory infertility patients.
Method: A total of 180 AI patients received by the Reproductive and Fertility Center of our hospital from October 2019 to October 2021 were selected and divided into three groups according to the treatment methods used by the patients . Intervention group A used intrauterine AIH after ovulation induction, intervention group B used AIH without ultrasound guidance after ovulation induction, and intervention group C used vaginal B-ultrasound guidance combined with AIH after ovulation induction. The general information, clinical indicators, treatment effects, and adverse pregnancy outcomes of the patients were recorded. Adverse pregnancy outcomes included biochemical pregnancy rate, multiple pregnancy rate, early miscarriage rate, and OHS. The study used binary logistic regression analysis to evaluate the risk of different pregnancy outcomes in different treatment paradigms , and evaluated the ROC sensitivity, accuracy, and specificity of pregnancy outcomes in different groups of patients with different types of AI.
Result: The three groups of AI patients were not statistically significant in terms of follicle-generating hormone, luteinizing hormone, estradiol, human chorionic gonadotropin daily endometrial thickness, the initial dose and total dose of ovulation-stimulating drugs, and the proportion of advancing sperm. difference. There were statistically significant differences in the number of ovulation cycles, average ovulation cycles, ovulation rate, implantation rate, biochemical pregnancy rate, early miscarriage rate, clinical pregnancy rate, multiple pregnancy rate and OHS among the three groups of subjects. The correlation between follicle -producing hormone and luteinizing hormone was 0.678, and the correlation between estradiol and human chorionic gonadotropin day endometrial thickness was 0.587, and they were all significant. Compared with the intervention group C, both the intervention group A and the intervention group B had a higher risk of early miscarriage, biochemical pregnancy, OHS, and multiple pregnancy outcomes. The ROC curve results are also consistent.
Conclusion: Ultrasound guidance combined with intracavity insemination in the treatment of AI patients can reduce the incidence of adverse pregnancy outcomes and has higher clinical value.
B-ultrasound, AIH, Ovulatory disorder infertility, Pregnancy outcome, Complication, ROC curve.