THE ROLE OF GLYCEROL AND SODIUM PENTABORATE FORMULATION ON COLONIC ANASTOMOSIS HEALING AND POSTOPERATIVE ADHESIONS IN RATS

Mirkhalig Javadov^{1, *}, Emrah Karatay², Alev Cumbul³, Suleyman Orman¹, Erhan Aysan¹ 

¹Yeditepe University Faculty of Medicine, Department of General Surgery - ²Istanbul Kartal Dr. Lutfi Kirdar City Hospital, Department of Radiology - ³Yeditepe University Faculty of Medicine, Department of Histology and Embriology

Introduction: We evaluated a new formulation of the mixture of glycerol and sodium pentaborate solution on colonic anastomosis healing.

Materials and Methods: Fourteen Sprague Dawley rats were randomly assigned into two equal groups. Segmenter right colon resection and single-layer end-to-end anastomosis was performed for all animals. The mixture of 2 ml 3% glycerol plus 3% sodium pentaborate formulation was injected in the study group, and 2 ml of 0.9% NaCl was injected into the peritoneal cavity in the control group. Rats were sacrificed after 21 days, and anastomosis bursting pressure, histopathological evaluations were assessed. 

Results: The mean postoperative peritoneal adhesions score was statistically lower (p<0.001) in the study group compared to the control, anastomosis bursting pressure and histopathologic fibrosis scores were high (p <0.001, p<0.0001; respectively). 

Conclusion: The mixture of 3% glycerol and 3% sodium pentaborate solution is effective for postoperative peritoneal adhesions prevention and inducing anastomosis healing processes.