THE EXPRESSION OF HIF-1α AND GNM IN GASTRIC CANCER AND PARACANCER TISSUES AND THEIR RELATIONSHIP WITH PATIENT PROGNOSIS

Lihong Shi^1*, XuanZhao¹, Hongli Gao²

¹Digestive system department, The second affiliated Hospital of Xuzhou Medical University, Xu Zhou 221000, China - ²Department of Medical, Hubei Minzu University, Enshi 445000, China

Objective: To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and glycine methyltransferase (GNM) in gastric cancer and paracancer tissues and their relationship with prognosis. 

Methods: Fifty patients with gastric cancer who received treatment in our hospital from January 2018 to January 2019 were selected as the research subjects. The expression of HIF-1α and GNMT in gastric cancer and paracancerous tissues was compared, and the relationship between expression and prognosis was analyzed by multivariate Cox regression. 

Results: The positive expression rate of HIF-1 in gastric cancer tissues was 84.0%, significantly higher than that in paracancer normal tissues (4.0%, P<0.001), and the positive expression rate of HIF-1 in gastric cancer tissues was 64.0%, significantly higher than that in cytoplasm (20.0%, χ² = 19.869, P<0.001). The expression of GNMT in gastric cancer tissues was (678.30±221.95) ng/ml, significantly lower than that in paracancer normal tissues (1136.76±332.85) ng/ml (P<0.001). Among the 50 patients, 32 survived, and 18 died. Multivariate logistic regression analysis showed that the expression of HIF-1 protein and GNMT protein, the degree of differentiation of cancer cells, and the depth of infiltration and lymphatic metastasis are independent risk factors affecting the survival and prognosis of patients. 

Conclusion: HIF-1 is highly expressed in gastric cancer tissues, and GNMT is poorly expressed in gastric cancer tissues. Both markers can be used as important indicators to judge the prognosis of gastric cancer patients.