RISK FACTORS FOR THE POOR OUTCOME FOLLOWING SURGICAL TREATMENT OF PATIENTS WITH USC

Qiumin He, Shuirong Zhang^*

Department of gynaecology, Jingzhou Central Hospital, Jingzhou Hubei 434000, PR China

Objective: To explore the risk factors of poor prognosis in patients with endometrial serous carcinoma (USC) undergoing surgery. 

Methods: The clinical data of 142 patients with USC who underwent surgical treatment in our hospital from January 2008 to December 2020 were retrospectively analyzed. The general data, surgical data, postoperative adjuvant treatment data and follow-up prognosis data were analyzed. Cox re-gression model was used to evaluate the independent risk factors of poor prognosis. 

Results: univariate analysis showed that age, lymph node resection, intraoperative peritoneal cytology, depth of myometrial invasion, staged operation, adnexal/uterine serosal invasion and omental metastasis were associated with the 5-year cumulative disease-free survival rate (P<0.05); Lymph node resection, staging operation, intraoperative peritoneal cytology, adnexal/uterine serosal invasion and postoperative adjuvant treatment were associated with 5-year cumulative overall survival rate (P<0.05); Multivariate analysis of Cox regression model showed that incomplete staged surgery and combined adnexa / uterine serosa invasion were independent risk factors for the decrease of 5-year cumulative disease-free survival rate (P<0.05); Unresected lymph nodes and positive intraoperative peritoneal cytology were independent risk factors for 5-year cumulative overall survival (P<0.05). 

Conclusion: the poor prognosis of patients with USC undergoing surgery is independently as-sociated with incomplete staging surgery, adnexal / uterine serosal invasion, unresected lymph nodes and positive intraoperative peritoneal cytology.