EXPLORATION ON THE PREDICTIVE VALUE OF MIR-181B FOR DEEP VENOUS THROMBOSIS OF LOWER LIMBS AFTER JOINT REPLACEMENT

Hong Zhang¹, Tong Xue², Changzhan Guo³, Qianqian Wang⁴, Huazeng Yin⁵, Wei Guo^{6, *} 

¹Department of Nursing, Shandong Handong Qingdao West Coast New Area Traditional Chinese Medicine Hospital(Shandong Qingdao Huangdao District Traditional Chinese Medicine Hospital), Qingdao 266500, Shandong Province, China - ²Hemodialysis Room, Shandong Handong Qingdao West Coast New Area Traditional Chinese Medicine Hospital(Shandong Qingdao Huangdao District Traditional Chinese Medicine Hospital), Qingdao 266500, Shandong Province, China - ³Shandong Qingdao West Coast New Area Disease Control and Prevention Center Office, Qingdao 266400, Shandong Province, China - ⁴Shandong Qingdao West Coast New Area Talent Market Health Subsector Office, Qingdao 266400, Shandong Province, China - ⁵Shandong Qingdao Huangdao District Market Supervision Authority Comprehensive administrative law - enforcement group of nine squadrons of the market - ⁶Department of Neurosurgery, Shandong Qingdao West Coast New Area Traditional Chinese Medicine Hospital(Shandong Qingdao Huangdao District Traditional Chinese Medicine Hospital), Qingdao 266500, Shandong Province, China

This study aimed to explore the predictive value of miR-181b for deep venous thrombosis of lower limbs after joint replacement. A total of 85 patients (DVT group) without DVT after joint replacement and 33 patients (DVT group) with DVT after treatment at the same time were compared. Differences in expressions of miR-181b between DVT group and non-DVT group were compared. The correlation between miR-181b and D-D dimer was analyzed. ROC curve was used to analyze the predictive value of miR-181b for DVT and logistic regression was used to analyze the risk factors of DVT. Expression levels of miR-181b in peripheral blood of patients from DVT group were significantly lower than those from non-DVT group (P<0.05). Expression levels of D-D dimer in peripheral blood of patients from DVT group were significantly higher than those from non-DVT group (P<0.05). Expressions of miR-181b in peripheral blood were negatively correlated with those of D-D dimer (P<0.05). miR-181b was expressed lower in peripheral blood of patients who were ≥60 years old, or patients with ASA grading II-III, diabetes and knee replacement (P<0.05). the AUC, critical level, sensitivity and specificity of DVT were respectively 0.880, 0.887, 96.97% and 69.41% predicted by miR-181b; the AUC, critical level, sensitivity and specificity of DVT were respectively 0.875, 1467μg/L, 96.97% and 74.12% predicted by D-D dimer; the AUC, sensitivity and specificity of DVT were respectively 0.953, 96.97% and 87.06% jointly predicted by both. Logistic multivariate analysis showed that ASA grading, operative site, miR-181b and D-D dimer were independent risk factors for DVT after joint replacement therapy (P<0.05). miR-181b has good predictive value for DVT after joint replacement, and may become a potential indicator for clinical prediction of DVT in the future, guiding clinical anticoagulant therapy.