EFFECT OF PARTIAL CYSTECTOMY ON SERUM VEGF AND CYFRA21-1 IN PATIENTS WITH MUSCLE INVASIVE BLADDER CANCER

Xiliang Chen¹, Jingqing Xia², Qiangyuan Qi¹, Fanlu Lin¹, Yingmin Xu¹, Li Zhang^{3, *}

¹Department of Urology Surgery,Linyi Central Hospital,Linyi, 276400, Shandong Province, China - ²Department of Hematology, Linyi Central Hospital,Linyi, 276400, Shandong Province, China - ³Medical Laboratory Diagnosis Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250031, Shandong Province, China

Objective: To explore the effect of partial cystectomy on serum VEGF and CYFRA21-1 in patients with muscle invasive bladder cancer (MIBC). 

Methods: 120 MIBC patients admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A (n=60) and group B (n=60) according to the order of admission. Group B underwent the radical cystectomy (RC), and group A underwent the partial cystetomy (PC). The operation indexes, serum tumor marker levels, postoperative complication rate (CR), recurrence and postoperative survival rate were compared between the two groups. 

Results: The operation indexes of group A were significantly better than those of group B (P<0.001); the levels of VEGF and CYFRA21-1 of group A after treatment were significantly lower than those of group B (P<0.05); the postoperative CR of group A was significantly lower than that of group B (P<0.05); and there was no statistical difference in the recurrence and postoperative survival rate between the two groups (P>0.05). 

Conclusion: Partial cystectomy can effectively remove the lesions and reduce the levels of serum VEGF and CYFRA21-1 in patients, with fewer postoperative complications, a low recurrence rate and relatively ideal curative effect, which should be popularized and applied.