DIFFERENCE ANALYSIS OF CLINICOPATHOLOGICAL DATA AND ORGAN FUNCTION RECOVERY IN PATIENTS WITH DIFFERENT PAIN SCORES AFTER HEPATECTOMY

Jie Li, Jiangtao Yu, Chaohui Wang, Weifeng Xu, Dachuan Shao, Jun Wang^*

Department of General Surgery, Fuyang People's Hospital of Anhui Province, Fuyang 236000, PR China

Objectives: To conduct a difference analysis of clinicopathological data and organ function recovery in patients with different pain scores after hepatectomy. 

Methods: One-hundred patients who underwent primary liver cancer resection in the Hepatobiliary Surgery Department of our hospital from January 2018 to September 2019 were selected, and all patients underwent liver cancer resection. After the operation, the degree of pain was evaluated according to the numerical grade method (NSR) = 3 as the critical value. Patients who had an NSR ≤3 were placed into the observation group (effective analgesia), and those with an NSR >3 were positioned into the control group (invalid analgesia). The preoperative and intraoperative clinicopathological data of two groups of patients were collected. The times of first exhaustion, first meal, first out of bed, placement of abdominal drainage tube, as well as days of hospitalization, liver function indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), prothrombin time (PT)], and serum T lymphocyte (CD₃⁺, CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺) levels were compared between the two groups. 

Results: The amount of bleeding in the observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05), and there was no statistically significant difference in other clinicopathological data between both groups (P>0.05). The times of first exhaustion, first meal, getting out of bed, placement of abdominal drainage tube, and hospitalization days of the observation group were significantly earlier than those of the control group; these differences were statistically significant (P<0.05). Postoperative ALT, AST, TBIL levels, and PT time of the observation group were significantly lower than those of the control group, and these differences were statistically significant (P<0.05). Postoperative T lymphocyte CD₃⁺, CD₄⁺, CD₈⁺, and CD₄⁺/CD₈⁺ levels in the observation group were significantly higher than those in the control group, and CD8+ levels were significantly lower than the control group. The differences were statistically significant (P<0.05). 

Conclusions: Patients undergoing liver cancer resection have varying degrees of immune function suppression, which is associated with increased intraoperative blood loss. Effective analgesic therapy can significantly reduce liver function damage in patients with primary liver cancer who underwent radical resection of liver cancer, and such therapy promotes liver function recovery relatively rapidly. Further, effective analgesic treatment could reduce medical costs and improve the postoperative treatment efficacy of patients with liver cancer.