CORRELATION BETWEEN SERUM SEX HORMONE LEVEL, ISLET FUNCTION LEVEL AND GLUCOSE AND LIPID METABOLISM IN PATIENTS WITH GESTATIONAL DIABETES MELLITUS

Maohua Ren^{1, *}, Linxiao Fan¹, Xiaoling Meng²

¹Department of Obstetrics, Shanxi People's Hospital, Taiyuan, PR China - ²Department of Pediatrics, Shanxi Children's Hospital, Taiyuan, PR China

Objective: To investigate the correlation between serum sex hormone level, islet function level and glycolipid metabolism in patients with gestational diabetes mellitus.

Methods: From August 2018 to October, 2019, 56 cases of gestational diabetes mellitus were randomly selected in the obstetrics and gynecology department of our hospital for our experimental group. In addition, another 56 cases of pregnant women with clean bills of health during the same period were selected as our control group. Next, we compared the basic clinical data of patients in each group. The levels of estrogen and progesterone in the two groups of pregnant women were determined through an enzyme-linked immunosorbent assay. Fasting insulin (FINS) levels in the two groups were determined by a double anti-centering method. The fluctuations in the insulin resistance index (IRI), insulin sensitivity index (ISI) and islet β cell secretion function (HOMA-β) were determined according to the formula. The changes of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) levels in the two groups of pregnant women were determined by the chemiluminescence method. The serum lipid index (total cholesterol [TC], triglyceride [TG], low-density lipoprotein [LDL], and high-density lipoprotein [HDL]) levels were measured in these women using an automatic biochemical analyzer. Following this, the Pearson correlation test was used to analyze the correlation between serum sex hormone level, islet function level, and glycolipid metabolism in patients with gestational diabetes mellitus.

Results: Compared with the normal group, the levels of estrogen, progesterone, FINS, IRI, FBG, HbA1c, TC, TG, and LDL in the study group were significantly increased, and the ISI, HOMA-β, and HDL levels were significantly decreased. The Pearson correlation analysis showed that estrogen and progesterone were positively correlated with serum FINS, IRI, FBG, HbA1c, TC, TG, and LDL levels and negatively correlated with ISI, HOMA-β, and HDL levels (P<0.05). 

Conclusion: The serum sex hormone, islet function, and metabolic levels of soup juice in patients with gestational diabetes mellitus were obviously abnormal compared with those in the control group of pregnant women. The former patients’ levels displayed obvious correlation, which could be used as an important index by which to judge the severity of gestational diabetes mellitus patients.