CLINICAL SIGNIFICANCE OF E-SELECTIN AND CTGF IN DIABETIC NEPHROPATHY, THEIR RELATIONSHIP WITH HBA1C AND INFLUENCING FACTORS OF DIABETIC NEPHROPATHY

Lihui Wang^{1, 2, #}, Jinhua Huang^{3, #}, Xuelun Wu², Xinsheng Li², Hongxia Qian², Jincheng Zhang², Mei Zhu^{1, *}

¹Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin300052, China - ²Department 1 of Endocrinology and diabetes mellitus, Cangzhou Central hospital, Cangzhou061001, Hebei Province, China - ³Department of Endocrinology, BeiJing Zhongguancun Hospital, Beijing100080, China 

Objective: This study aims to explore the clinical significance of E-selectin (E-S) and connective tissue growth factor (CTGF) in diabetic nephropathy (DN). 

Patients and methods: A total of 127 patients with diabetes admitted to our hospital were selected as the research objects and analyzed prospectively. Among them, 61 patients combined with nephropathy were divided into a research group. The other 66 patients with simple diabetes were divided into a control group. The levels of E-S, CTGF and HbA1c in serum of patients between the two groups were compared. 

Results: E-S, CTGF and HbA1c in the research group were significantly higher than those in the control group (p<0.001). Pearson correlation coefficient analysis showed that E-S, CTGF and HbA1c in the research group were positively correlated (p<0.001). ROC curve analysis showed that the combined detection of E-S and CTGF had good predictive value for the occurrence of DN in diabetic patients. Logistic regression analysis showed that fasting blood glucose, glomerular filtration rate, urinary albumin excretion rate, urea nitrogen, creatinine, E-S and CTGF were independent risk factors for DN in diabetic patients. 

Conclusions: E-S and CTGF are significantly increased in DN patients, and are positively correlated with HbA1c, which is expected to be an early screening index for DN in the future.