ANALYSIS OF SERUM CYSTATIN C LEVELS IN HEALTHY INDIVIDUALS IN NANCHONG (SICHUAN PROVINCE, CHINA)

Lingli Ren^1,#, Chunhui Chen^2,3,#, Xiang Long^2,3, Zhirong Jiang^2,3, Dan Wang², Qing Meng⁴, Lin Long^1,2,*, Xiaobing Tian^5,*

¹Department of Rheumatism and Immunity, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China - ²Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China - ³School of Nursing, North Sichuan Medical College, Nanchong 637000, China - ⁴Ministry of Science and Technology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China - ⁵Preventive Medicine Department, North Sichuan Medical College, Nanchong 637000, China

Objective: The aim of the present study was to investigate the distribution and abnormal detection rate of serum cystatin C (CysC) levels in healthy individuals in Nanchong (Sichuan Province, China).

Methods: A group of healthy individuals undergoing physical examinations at a tertiary A hospital in Nanchong City from January to August 2018 was studied to compare serum CysC levels and their abnormal detection rates as a function of age, sex, blood pressure, blood glucose, blood lipids, and body mass index (BMI).

Results: Serum CysC levels and their abnormal detection rate in healthy individuals were 0.79±0.25 mg/L and 8.5%, respectively, which gradually increased with age. At different ages, the abnormal detection rate was significantly higher in males than in females (P<0.05). For individuals under 60 years old, serum CysC levels were higher in males than in females (P<0.05). Individuals who were overweight or obese, had high blood pressure, or had abnormal blood lipids had higher serum CysC levels and abnormal detection rates than those with normal or low BMIs, normal or low blood pressure, or normal blood lipids, respectively (P<0.05).

Conclusions: Serum CysC levels and abnormal detection rates were high in our Nanchong cohort. Hence, public health departments should strengthen the prevention and treatment of chronic kidney disease, especially in individuals who are overweight/obese or have high blood pressure, abnormal blood lipids, or high blood glucose.