THE EXPRESSION AND CLINICAL VALUE OF SP-A AND STAT3 IN CHRONIC SINUSITIS WITH NASAL POLYPS

Guanghua Zou, Jianqi Gong, Xinri Zhang, Ling Tie, Hongxia Xu, Wei Zhang^* 

Department of Otolaryngology, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, PR China

Objective: To analyze the expression and clinical value of SP-A and STAT3 in chronic sinusitis with nasal polyps (CRSwNP). 

Methods: Patients who underwent preoperative nasal endoscopy and sinus CT examination in our hospital from January 2019 to January 2020 were collected and divided into a chronic sinusitis group (n=52), a CRSwNP group (n=124), and the control group (n=40). According to the clinical classification and staging of chronic sinusitis and nasal polyps and the evaluation criteria for the efficacy of endoscopic sinus surgery, the CRSwNP components were divided into a type II stage 1 group (n=26), type II stage 2 group (n=35), type II stage 3 group (n=36), and type III group (n=27). The collected tissue pieces were made into paraffin sections, STAT3 was measured by immunohistochemistry PV6001 method, and SP-A level was measured by the conventional immunohistochemistry streptomyces antibioprotein-peroxidase staining method. A Kappa test was used to evaluate the consistency of SP-A and STAT3 positive rates with pathological results. 

Results: The positive rates of SP-A and STAT3 in the CRSwNP group and chronic sinusitis group were significantly higher than those in the control group. The positive rates of SP-A and STAT3 in the CRSwNP group were significantly higher than those in the chronic sinusitis group, and the difference was statistically significant (P<0.05). There was no significant difference in the positive rates of SP-A and STAT3 among patients with different nasal polyps groups (P>0.05). The sensitivity of SP-A for diagnosing CRSwNP was 77.42%, and the specificity was 86.96%. The sensitivity of STAT3 for diagnosing CRSwNP was 74.19%, and the specificity was 85.87%. The sensitivity of the two combined diagnosis of CRSwNP was 88.26%, and the specificity was 92.38%. 

Conclusion: SP-A and STAT3 have significantly high expression in CRSwNP patients. The extent of inflammation and the severity of lesions do not affect the expression of SP-A and STAT3. Both have certain value in the diagnosis of CRSwNP, and the combination of the two is of high value and can be widely used in clinical practice.