LONG-TERM PROGNOSTIC SIGNIFICANCE OF LNCRNA SOX2OT IN COLON CANCER

Zhichao Zhang¹, Jun Wang², Jinming Wei³, Chuxiong Li^{1, *} 

¹Department of Emergency, The People 's Hospital of Hanchuan, 431600, Hubei Province, China - ²Department of Hepatobiliary Surgery, Yuxi People's Hospital of Yunnan Province, Yuxi, 653100, Yunnan Province, China - ³Department of Anorectal, Hanchuan Traditional Chinese Medicine Hospital, Hanchuan, 431600, Hubei Province, China

Objective: Colon cancer (CC) is a prevalent malignancy with unfavorable prognosis, highly latent in the early phase. Its prevention and treatment primarily lies in accessible effective blood markers. This study was for analyzing the clinical value of SOX2OT in CC to offer dependable reference and guidance for future clinical practice. 

Methods: Totally 74 patients with CC in our hospital between May 2014 and June 2015 were enrolled, and 68 healthy individuals were also enrolled meantime. SOX2OT in their serum and tissues was quantified, and its association with the development/progression/metastasis of CC was studied. All patients were followed up for 5 years for analyzing the value of SOX2OT for cases with CC. 

Results: With a high concentration in the serum and cancer tissues of patients with CC, SOX2OT possessed a high value in forecasting the development/progression/metastasis of CC. Additionally, with a decrease after treatment, it performed remarkably in forecasting the death of patients, and its increase foretold an increased risk of death. 

Conclusion: SOX2OT possesses a high value in forecasting the development/progression/metastasis of CC, and its high level foretells a raised risk of unfavorable prognosis.