Influence of the Type and Number of Complications on Platelet Function in Acute Cerebral Infarction Patients

Aixia Song, Hongmei He, Qian Xue

Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, 075000, Hebei Province, China

Objective: To investigate the influence of the type and number of complications on platelet function in patients with acute cerebral infarction (ACI). 

Methods: The baseline clinical data of 386 ACI patients admitted to our hospital from January 2017 to December 2019 were analyzed retrospectively. All patients were grouped according to the type and number of complications, included 67 cases without complications, 70 cases with diabetes, 139 cases with hyperlipidemia, 168 cases with hypertension, and 42 cases with two or more complications. The level of maximum aggregation rate (MAR) before and after treatment was detected, and the influence of MAR level on the National Institutes of Health Stroke Scale (NIHSS) score and modified Rankin Scale (mRS) score was analyzed. 

Results: Before treatment, the MAR levels in the multi-complication group, diabetes group, hy-perlipidemia group, hypertension group and non-complication group showed a trend of decreasing in turn (P<0.05). 2d, 7d and 4w after treatment, the MAR levels in these groups at were significantly lower than before treatment (P<0.05). After 12 weeks of treatment, the MAR levels in the multi-complication group, diabetes group and hyperlipidemia group were significantly higher than those in the non-complication group and hypertension group (P<0.05). After 12 weeks of treatment, the MAR levels in the multi-complication group, diabetes group and hyperlipidemia group showed a trend of decreasing in turn (P<0.05). The NIHSS score and mRS score decreased with the decrease of MAR level in the non-complication group, diabetes group, hyperlipidemia group and hypertension group (P<0.05). The NIHSS score and mRS score decreased with the decrease of MAR level in the multi-complication group (P<0.05). 7d after treatment, the decrease of MAR level in the multi-complication group was higher than that of NIHSS score and mRS score (P<0.05). 

Conclusion: Higher platelet aggregation ability is observed in ACI patients, and the detection of MAR level can be used to evaluate the severity of the disease and the efficacy of antiplatelet drugs.