EXPLORING MULTIFACTOR-MEDIATED DYSFUNCTIONAL MODULES IN PSORIATIC AND PREDICTING POTENTIAL DRUG TARGETS

Tao Li^*, Xiaozhong Huang 

Dermatology & STD Department, Maoming People’s Hospital, Maoming, 525000, China

Psoriasis is a chronic inflammatory skin disease that is long-lasting and prone to recurrence, seriously affecting the health and mental state of patients. However, we still know very little about its pathogenesis and treatment. Therefore, this study explores the psoriasis dysfunction module mediated by multiple regulators to predict its potential drug and drug targets. In this work, we identified 23 dysfunctional modules based on the co-expression of potential pathogenic genes and functional and KEGG pathway enrichment. Further, by deciphering the regulators of these dysfunctional modules, we revealed a series of genes (including CDK1, UBE2N and MAPK8, etc.), ncRNAs (including miR-92a-3p, miR-146a-5p, etc.) and transcription factors (including TP53, RELA, NFKB1, STAT1, etc.) may be involved in the pathogenesis of psoriasis. Finally, based on these multifactor-mediated dysfunctional modules, we predicted potential drugs for the treatment of psoriasis (including copper, polaprezinc, zinc, etc.), which have significant regulatory effects on dysfunction and may have pharmacological or toxicological effects for psoriasis. We observed the effects of these drugs on the module genes and predicted the potential drug targets of these drugs (including S100A2, S100A4, APP, etc.). These potential drugs and targets provide a valuable reference for drug developers to conduct drug re-positioning and new drug development. In summary, the strategy for exploring the multifactor mediated dysfunction modules provides a new way to discover the underlying pathogenesis of psoriasis and its treatment strategies, which can also be widely applied to other disease research.