EFFECT OF XUEBIJING COMBINED WITH ANTIBIOTICS AND FIBEROPTIC BRONCHOSCOPE SPUTUM ASPIRATION AND LAVAGE ON SERUM INFECTION INDEXES AND INFLAMMATORY FACTORS OF ICU PATIENTS WITH SEVERE PNEUMONIA

Liqing Peng^#, Qianfang Liang^#, Rong Lu, Ruixiang Zhou^* 

Department of Critical Care Medicine, Wuhan No.1 Hospital, Wuhan, 430022, China

Objective: The purpose was to study the therapeutic effect of Xuebijing combined with antibiotics and fiberoptic bronchoscope sputum aspiration and lavage on ICU patients with severe pneumonia, and analyze its effect on serum infection indexes and inflammatory factors. 

Methods: 100 patients with severe pneumonia admitted to ICU of our hospital from January 2018 to December 2019 were randomly selected and divided into control group and experimental group by drawing lots, with 50 cases in each group. The patients in the control group were treated with antibiotics combined with fiberoptic bronchoscope sputum aspiration and lavage while the experimental group was treated with Xuebijing on the basis of the control group to compare the treatment effective rates, incidence of adverse reactions, serum infection indexes (CRP and PCT) and inflammatory factors (IL-6 and IL-8) after treatment between the two groups. 

Results: The treatment effective rate in the experimental group was significantly lower than that in the control group, with a statistically significant difference (P<0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group, with a statistically significant difference (P<0.05). The CRP and PCT expression levels in the experimental group were significantly lower than those in the control group after treatment, with statistically significant differences (P<0.05). After treatment, the IL-6 and IL-8 expression levels in the experimental group were significantly lower than those in the control group, with statistically significant differences (P<0.05). 

Conclusion: Xuebijing combined with antibiotics and fiberoptic bronchoscope sputum aspiration and lavage has better therapeutic effect on ICU patients with severe pneumonia, which can significantly reduce the expression levels of serum infection indexes and inflammatory factors in patients with severe pneumonia, with high clinical application value.